Unwanted veins on the legs come in all shapes and sizes. Varicose veins are large, bulging, blue veins that are often painful. The best ways to get rid of these are by surgically stripping them out, by sclerotherapy injections, or by newer ways that irritate these big veins by using laser light or radiofrequency administered from inside the vein. Lasers administered through the skin are not very helpful for true varicose veins. Spider veins are often red or blue and come in a variety of sizes. These veins can be removed with either sclerotherapy injections (where an irritating solution is injected into the veins) or by laser treatment. In general, the largest spider veins over 1-2 mm respond best to sclerotherapy injections, in my opinion. Most other veins respond best to laser treatment.